Journal List
ID5241
Title Texto Livre: Linguagem E Tecnologia
E ISSN 1983-3652
P ISSN -
Country Brazil
Impact Factor Awaiting
Publication year 2008
Publisher NameFaculdade de Letras, Universidade Federal de Minas Gerais
FrequencyQuarterly
Indexed Yes
Website http://www.periodicos.letras.ufmg.br/index.php/textolivre/


SIS Advertise









News

Rutherford is the founder and executive director of the nonprofit environmental organization Ocean Research Project, which gathers and analyzes marine data from a sailboat. His route took him around the southern tip of Greenland, through the Denmark Strait and into the Greenland Sea. From there, he sailed through the Norwegian and Barents seas, and reached Russia's Novaya Zemlya archipelago in mid-August.

He was planning to continue to Canada and end his journey where it started, but Russian officials halted him in his tracks and ordered him to turn around.

On his way home, Rutherford told Live Science about his adventures and why he wants to complete this loop. In an interview on Sept. 23, he also revealed what he'll do differently on his next attempt to avoid another Russian interception.

Sascha Pare: Where are you currently, and what are the conditions like?

Matt Rutherford: I'm about halfway between Greenland and Newfoundland in the Labrador Sea. The conditions aren't too bad; I mean, it's close to a gale, but it's not quite a gale. [Editor's note: A gale is defined as an area of sustained surface winds of 34 to 47 knots (39 to 54 miles per hour).] It's just a little hard to do anything. I've got dishes in the sink that are all wedged in there that I really need to deal with ‪—‬ but I don't feel like it, because you're just getting tossed around. Waves are crashing on the cockpit. Normally, I do video calls under a dodger [a canvas screen on a boat or ship that provides protection from spray], and you can see the ocean in the background… But I'm going to get hit by a wave if I do that.

SP: You're sailing home to Maryland after a rather perilous expedition. How long have you been at sea for?

MR: I left in mid-May, and I've been basically underway for the most part since then. At this time, currently, I've only been at sea for a few days, because I left Greenland a few days ago. The longest stretch I was continuously at sea this year is 59 days, although I was planning on doing longer than that, so that sucked. Essentially, I was attempting to do a nonstop, single-handed circumnavigation of the Arctic. That's where this all sort of came out of. I tried in 2018, but you couldn't get the Russian permits. And the Russians were the problem in the end [this year]. I got defeated by Russian bureaucracy, essentially. And there was some weird stuff going on with the ice up there this year. [Editor's note: Sections of the High Arctic were impassable due to a relatively cold summer and solid ice fields.]

Rutherford's route took him close to Russia's coast, where the FSB intercepted him. (Image credit: Ocean Research Project)

SP: What happened with the Russians that forced you to turn back?

MR: The FSB got me. [Editor's note: The Federal Security Service (FSB) is Russia's main security agency and a successor to the Soviet Union's KGB.] They boarded me twice, actually. I've never been boarded in the ocean in my life, and I've been sailing 20 years, all over the place. I got about 1,000 miles [1,600 kilometers] into Russia, roughly. I got into the Northern Sea Route. If you just draw a line due north, I was due north of West China — it was way over there, about halfway around the world in the Arctic. I made it about halfway, because I started in Aasiaat, Greenland.

They boarded me once, and then they turned me around and boarded me again. It's a bit of a strange situation, I guess. Two days after I turned around, the ice that I was waiting to open opened, and I sent them an email — the NSRA, the Northern Sea Route Association in Moscow — and said, "Hey, it's open. Can I pretty please go?" And they just got mad at me, like, "You'll be in violation of your permit; you have to turn around."

SP: You're planning to try the circumnavigation again next year. Will you do anything differently to make sure you complete it?

MR: The boat's pretty good to go ‪—‬ which is great, because that's a huge time sink. Ideally, hopefully, if I can get north of [the Norwegian archipelago] Svalbard again like I did this year, then I'm going to stay north of [the Russian archipelago] Franz Josef Land, and I'm going to basically ride the polar ice cap all the way from Svalbard to the Northwest Passage — all the way to Alaska and beyond, essentially.

Because I've learned how the FSB operate, and I know where they're keeping their ships now. Even though I was north of Novaya Zemlya, they still were able to get me. But if I'm over there, north of Frank Josef, they don't go that far, so they won't be able to get me up there. I've figured out a couple of other things that I'm not even going to say, honestly ‪—‬ there are workarounds to get them to [leave me alone]. I'm going to go a little bit quiet.

The NSRA gives you the permit to do this, but the FSB are the people who patrol it. And the FSB don't like the NSRA. I learned that when they boarded me, because they think that they're the ones who should control the Northern Sea Route, not the NSRA. So there's [a] beef between them; they don't talk. There's a lack of communication, which benefits me. I can lean heavy onto the NSRA side, because they don't have boats; they're not going to board you. And they're the ones you have to check in with every 24 hours in Moscow; you've got to send them an email every 24 hours. So I'll do all of that stuff with those guys, but I think there's some ways I can avoid the FSB even knowing where I am, essentially, while still complying with my permit in the NSRA.

Basically, I've got to do the Northern Sea Route without getting within 12 miles [19 km] of any Russian land, period ‪—‬ even a little island, even a rock that sticks out that's 10 feet by 10 feet [3 by 3 m]. That's going to be real tricky, because there are a lot of little islands down there. But the FSB is mostly on the European side; they have almost no boats over on the east side or the middle. So if you can get past the European side by hugging the coast way the hell north, hopefully I can get past where they patrol, and then I can just shoot on through.

Nobody else in the world does this ‪—‬ nobody else in the Arctic, nobody else anywhere. There's literally no other body of water on Earth where you've got to get permits, and then you've got to get boarded like this. It's only Russia, and only north of Russia. And that's because there's a huge amount of natural gas, they think, buried above Russia. So Russia's trying to claim everything to the North Pole.

Technically, it's international waters, so the U.N. is like, "No, this is not right." And Russia's like, "Whatcha gonna do about it?" It's kind of hard to argue with that ‪—‬ and it's north of Russia, so nobody else is there. They've got free rein, and they've got all the icebreakers and whatever else.

Everything else is about the same. I need to secure my hot sauce better, because every time I open my cabinet, they fall out all over the place. There's little things like that ‪—‬ quality-of-life things. I'll probably bring some more heated socks — electric socks and electric gloves. I'll try to make better videos — but I'm not a content creator, and I don't want to be an influencer.

Rutherford will make another attempt at circumnavigating the Arctic next year. (Image credit: Matt Rutherford)

SP: Can you tell me a bit about your background and what led you to this point?

MR: I did this whole circumnavigation of the Americas — nonstop, single-handed — back in 2011 where I spent 309 days alone at sea on this little 27-foot (8 meters) boat. When I got back from that big, crazy trip — which I made a documentary about ["Red Dot on the Ocean: The Matt Rutherford Story"] — I created a nonprofit called Ocean Research Project, where, basically, we use sailboats to do research. We focused mostly in 2013 and 2014 on garbage-patch-related microplastics. In 2013, we mapped out the eastern side of the Atlantic garbage patch, because nobody had got to the eastern side of it. I think it was 160,000 pieces per square kilometer, or something like that. And then, we did some stuff in 2014 in the Pacific garbage patch with the University of Tokyo; we did a joint paper with them.

But mostly what we focus on is Arctic research. Since 2015, we've been heading up to Greenland — sometimes the Northwest Passage also, but primarily Greenland — doing research related to glaciers, for the most part. An ocean-terminating glacier sort of has a river of melted water underneath it, and it creates upwelling, and the upwelling has nutrients. So it mixes nutrients with the ocean and creates this perfect recipe for growth for phytoplankton and zooplankton. And then, we look at the different stages of decay between an ocean-terminating glacier, a land-retreated glacier or a deglaciated fjord. In the middle phase, when a glacier starts retreating back on land, it just creates a river of muddy water, essentially; it turns the fjord into a mud puddle. You can't have photosynthesis if you're in a mud puddle.

The Ocean Research Project is a nonprofit studying the Arctic and Chesapeake Bay. (Image credit: Matt Rutherford)

SP: Have you been collecting samples or data on this expedition?

MR: Well, it's a little tricky on a boat under these circumstances. I took 50 samples, which were just water samples, and those were from Newfoundland to Aasiaat, Greenland. Nicole [Nicole Trenholm, Ocean Research Project's science director] has a NASA internship out at JPL [Jet Propulsion Laboratory]. She was publishing a paper looking at their model that they have [ECCO-Darwin], and I've kind of forced my way into the paper — well, the organization did, with Nicole's help — by adding these samples. Now we have in situ data, physical data, that we can compare to the model data. That was the only thing we did this year. It's a couple-thousand-mile stretch with 50 water samples in it, so it's a pretty straightforward sort of thing.

Nicole is trying to publish multiple peer-reviewed scientific papers from our previous data. She's got a traffic jam of data, so she needed some time to finish publishing papers from stuff we've collected over the last few years. There is no money anyways. I could still grab some samples on the way up there [Greenland]. And it's trying to promote the nonprofit through it, because people will pay a lot more attention to this stuff than they pay to traditional research expeditions.

SP: What are your hopes for the Ocean Research Project once you tick off this goal?

MR: Basically, we're trying to expand the organization over the next couple of years. I'd like to bring in another one or two more scientists, because we're up there for three months in Greenland, and sometimes we go to the Northwest Passage — and it's a lot for one scientist.

The big problem we're having is that when Elon Musk was part of DOGE [U.S. Department of Government Efficiency], they cut a massive amount of polar funding — something like 88% of it — because apparently climate change is a hoax and they hate it and you're not allowed to research it either, right?

Basically, nobody's got money. We don't typically get NSF [National Science Foundation] funding; we get more foundation funding, because it's hard to get NSF funding, even before all this stuff. Now that the funding has been cut on the governmental level, a lot more scientists are going after the foundation grants that we used to have a lot less competition for. That makes it a little tricky, too, because now they're getting a flood of requests that they didn't usually get in the past.

This interview has been condensed and edited lightly for clarity.

Help us improve Live Science Pro: We're always trying to make our content better. Leave us feedback about Pro here.

'> 'The Russians were the problem in the end': Sailor Matt Rutherford on being intercepted by the FSB while attempting to circumnavigate the Arctic O...proving the visionary physicist right yet again.

The researchers published their findings Sept. 15 in the journal Physical Review Letters.

Neutron stars are the collapsed cores of massive stars that exploded as supernovas. Each packs more mass than the sun into a ball roughly 12 miles (20 kilometers) in diameter. Some, called pulsars, spin rapidly and sweep beams of radio waves across the sky like cosmic lighthouses. Their rotation is so steady that their pulses work as extraordinarily precise clocks.

Very few pulsars orbit another neutron star. "There are only 30 such double neutron star systems, and the relativistic effects are very strong if they are in compact orbits," study co-author JinLin Han, an astronomer at the National Astronomical Observatories of the Chinese Academy of Sciences, told Live Science via email.

The first such pair, discovered in 1974 and known as the Hulse-Taylor binary, provided the first evidence for gravitational waves — ripples in space-time predicted by Einstein. Such waves carry energy away from an orbiting pair, so its orbit should gradually shrink, and the Hulse-Taylor orbit shrank at just the rate Einstein's theory predicted.

Later, the "double pulsar," which completes an orbit every 2.45 hours, matched the predicted rate to within about 0.01%. Eventually, this shrinking forces such pairs to merge, unleashing gravitational waves like those the Laser Interferometer Gravitational-Wave Observatory and Virgo interferometer picked up in 2017.

A newly discovered pair

The new system, designated PSR J1856-0039, lies roughly 4,200 to 6,500 light-years from Earth. In 2020, it turned up in a survey of the Milky Way's disk by China's Five-hundred-meter Aperture Spherical Radio Telescope (FAST), the world's largest single-dish radio telescope.

"We have discovered about 900 pulsars," Han said of his team's work. "After a few follow-up observations, this one is very extraordinary."

The pulsar spins about 43 times per second, and the two stars are separated by roughly twice the distance between Earth and the moon. But the "most attractive feature" is the short orbital period of about 2.36 hours, Han said. "This is the second-shortest one, and it must show stronger relativistic effects than the famous double pulsar and the Hulse-Taylor system."

The team observed the pair with FAST 17 times between 2020 and 2025, sometimes long enough to cover a whole orbit. The researchers measured the arrival times of the system's pulses and then fit that data to orbital models that accounted for relativistic effects, like subtle changes to the pulse arrival times at different parts of the stars' orbits.

"With so many measurements by FAST, which would be hard to match in accuracy with other telescopes, we got not only the basic parameters of the pulsar and its orbit but also three relativistic effects," Han said.

First, the orbit is shrinking as the stars radiate gravitational waves, drawing them about 9 feet (2.7 meters) closer each year. Second, the oval orbit turns slowly, by 17.6 degrees per year — some 150,000 times faster than the relativistic drift of Mercury's orbit. Third, because both gravity and speed slow time, the pulsar's clock runs at a varying pace along the oval orbit, shifting its pulses by up to about half a millisecond.

An illustration of two neutron stars generating gravitational waves (purple) as they spiral toward each other in a tightening binary orbit. The rate of this orbital shrinkage offers a natural test of Einstein's theory or relativity. (Image credit: ESA)

"From these measurements, we determined the pulsar mass and the companion mass," Han explained. "The total mass is the lowest among all known double neutron star systems." The pulsar weighs about 1.3 times as much as the sun, and its companion is just 1.19 solar masses — one of the lowest-mass neutron stars known. Simulations suggest that supernovas can't forge neutron stars much lighter than that.

The stars will merge in about 82 million years. That merger will probably leave behind a heavier neutron star of about 2.26 solar masses, though the remnant could instead collapse into a black hole, the researchers estimate.

Another win for Einstein

Any two of the three effects are enough to calculate both stars' masses. The third then serves as an independent check, because if general relativity is correct, all three must point to the same masses — and they do.

"We found that general relativity is needed to explain the data, and the consistency is about 1%," Han said. The double pulsar test is more precise, but it drew on 16 years of data, compared with about five for the new pair. "Unfortunately, we could not beat this description of gravity," Han added, referring to physicists' hope of finding cracks in Einstein's theory that might reveal new physics.

Next, the team hopes to detect "frame dragging," an effect in which a spinning mass twists space-time around it, making nearby orbits wobble. "In the future, we will monitor this pulsar, probably over decades, to detect the frame dragging induced by the neutron star's spin," Han said.

Measuring the effect would reveal the pulsar's moment of inertia, which depends on how its mass is spread out inside. That would provide "a novel constraint" on how matter behaves at the crushing densities in neutron star cores, Han said — one of the biggest open questions in physics.

See how much you know about black holes with our black hole quiz!

'> Lightest known pair of neutron stars proves Einstein right yet again

Finally, the doctors agreed with the initial diagnosis: The pilot was experiencing migraines. The causes of migraine are not fully understood, although genetics and environmental factors may contribute to both the duration and intensity of migraine pain in a given individual.

Three gray fighter jets float amidst clouds in the sky.

Indian Air Force (IAF) fighter jets photographed in 2019. The patient's headaches were sometimes so bad that they stopped him from conducting scheduled flights. (Image credit: Abhishek Singh via Getty Images)

The treatment: The pilot was given the migraine medicine sumatriptan, to be taken at the first sign of pain, and aspirin, to be taken during headaches. He was allowed to continue flying under restricted conditions, and he had to report to a military neurologist for monthly reviews over the next three months.

Four months later, he was headache-free and had stopped taking medication, according to the report. However, his superior officers needed a detailed medical review before they could restore his unrestricted flight status, as severe migraines can disqualify pilots from flying.

Over three days, doctors conducted in-depth interviews with the pilot, focusing on the first appearance of his symptoms and the circumstances leading up to his headaches. They were puzzled by certain details: His lack of nausea, vomiting and auras, and the fact that he got no relief through sleep. These facts raised questions about the migraine diagnosis.

During the interviews, the pilot recalled that his headaches began around the time that he started using a new type of helmet with a tighter fit. The headaches corresponded with days in which he flew multiple flights and became worse the longer he wore the helmet. Then, around the time he started taking the prescribed medication, he coincidentally received a new allotment of personal flying clothing — including a helmet that was the correct size — for a new plane assignment. His headaches suddenly stopped.

"At that point the officer did not connect the cessation of headaches with the use of the new helmet," the doctors reported. "Reviewing the case in its entirety, the diagnosis of migraine or vascular headache was found to be incorrect; instead the individual was suffering from external compression headache due to an ill fitting helmet."

Compression headaches are caused by tight external pressure on the scalp and forehead, and they typically resolve when the pressure eases.

Doctors instructed the pilot to keep a headache diary and scheduled follow-up visits to confirm their findings. Five months later, his headaches had not returned, as he'd continued using the better-fitting helmet.

What makes the case unique: When the military doctors scoured peer-reviewed studies, they found no reports of similar instances of compression headache "in any of the Air Forces of the world," they wrote in the report.

This case, they added, emphasizes the medical significance of making sure that pilots' flight uniforms — especially their helmets — fit properly.

For more intriguing medical cases, check out our Diagnostic Dilemma archives.

This article is for informational purposes only and is not meant to offer medical advice.

Can you guess the diagnosis in these strange medical cases? Find out with our diagnostic dilemma quiz!

'> A fighter pilot had unexplained headaches for over a year. The cause was hiding in plain sight.

Westminster's chief mason unearthed the stone sarcophagus in 1869, but when experts investigated it, they discovered that the burial had been looted earlier that century. Experts also noticed that the carved decoration on the side of the sarcophagus was stylistically Roman, with a Latin inscription that can be translated as "To the memory of Valerius Amandinus. Valerius Superventor and Marcellus made this for their father." But an enormous medieval cross had been carved into the lid of the sarcophagus, suggesting that the tomb had been reused to bury an important religious figure hundreds of years later.

The mystery of the medieval individual buried in a Roman sarcophagus remained unsolved for 150 years, as no one thought that any bones were left inside. But when the stone coffin was opened for conservation in 2016 and a full skeleton was discovered, clues to the identity of the deceased finally came to light, Warwick Rodwell, the consultant archaeologist for Westminster Abbey, wrote in a study published Wednesday (Oct. 21) in the Journal of the British Archaeological Association.

Although the skeleton had been disturbed over the years, with a hole accidentally made in the skull and arm and leg bones mixed up, it was clear that the person was male, middle-aged, and of average height, bioarchaeologist James Langthorne of Pre-Construct Archaeology wrote in a 2016 report. The man also had some evidence of osteoarthritis, two healed rib injuries and gout. The bones were carbon-dated to between 987 and 1052, confirming that the Roman-era sarcophagus was reused in the Middle Ages.

a limestone sarcophagus whose lid has been carved into a large cross
Dean & Chapter of Westminster
a black-and-white photograph of the side of a Roman sarcophagus showing an inscription
Dean & Chapter of Westminster
an aerial view of an excavation showing walls and the burial pit where a Roman sarcophagus was placed
© Pre-Construct Archaeology Ltd; (CC-BY-ND 4.0)
a human skeleton fully laid out in a sarcophagus but with several bones misplaced
© Pre-Construct Archaeology Ltd; (CC-BY-ND 4.0)
two views of a human skull showing post-mortem damage and reconstruction
© Pre-Construct Archaeology Ltd; (CC-BY-ND 4.0)

"This brings us to the final question of importance: who was he?" Rodwell wrote in the study. Despite the lack of grave goods, which may have been stolen in the early 19th century, "he was almost certainly an abbot" who was given a dignified burial in a stone sarcophagus with a large cross, Rodwell wrote.

Based on the birth and death dates of the abbots of Westminster and their tenure as clergy, Rodwell narrowed the candidates down to Wulfsige (abbot from 988 to 993), Ælfwig (abbot from 993 to 1020) and Wulfnoth (abbot from 1020 to 1049). Given that Wulfsige left Westminster to become a bishop elsewhere, he was likely not buried in the abbey.

"Consequently, we have two viable contenders for the occupant of the sarcophagus," Rodwell wrote. "The fact that Ælfwig was already a monk of Westminster might favour him."

Although the final resting place of Ælfwig may have been found after a millennium, some questions remain unanswered.

For example, it is unclear why an 11th-century abbot was buried in a recycled fourth-century Roman sarcophagus. The reuse of Roman coffins is extremely unusual, Rodwell noted in the study, and nothing comparable to this sarcophagus has ever been found. One explanation for the reuse may rest with the Latin inscription, whose first word — "memoriae" (to the memory) — suggests that Valerius Amandinus was an early Christian himself. This Roman may have been a significant figure in Roman London, Rodwell wrote, but "unfortunately, nothing is known about his career."

Experts are also unsure where the Roman sarcophagus came from. It was made from limestone sourced from Oxfordshire, a county in the South of England. But perhaps the coffin was originally buried in a Roman mausoleum and they were unearthed and moved at some point, Rodwell noted. But as Rodwell pointed out in the study, "there could be a villa and its cemetery somewhere in the vicinity of Westminster Abbey, awaiting discovery."

The sarcophagus is currently on display in the Queen’s Diamond Jubilee Galleries at Westminster Abbey.

What do you know about the Empire's conquest of the British Isles? Find out with our Roman Britain quiz!

'> Case of mysterious medieval skeleton buried in Roman-era sarcophagus at Westminster Abbey finally solved

While research has long linked a scrambled circadian rhythm to a risk of mood disorders, neuroscientists are now proposing that these disruptions define a specific form of depression that they call "circadian depression." First conceptualized in 2021, the body-clock subtype may affect about 1 in 4 people with severe, recurrent or persistent depression, the researchers estimate.

In their new study, published Wednesday (Oct. 21) in The British Journal of Psychiatry, the team identified the subtype in about 2,600 people out of over 11,000 evaluated.

"Circadian depression is a biologically informed subtype," said study co-author Emiliana Tonini, a neuroscientist at the University of Sydney. "Unlike subtypes defined mainly by symptoms, the core feature here is a disturbed circadian system, which common antidepressants may not fully address," Tonini told Live Science in an email.

The researchers think treatments that target the sleep-wake system, such as the sleep hormone melatonin or bright light therapy, might be beneficial for people with this subtype. However, because the subtype is still a proposal and not formally established yet, other experts say that further research is needed before the findings can inform clinical practice.

More than just bad sleep

Tonini and her team analyzed data from 11,380 adults ages 18 to 90 who took part in the Australian Genetics of Depression Study (AGDS), a nationwide study exploring how genes and life experiences influence depression and responses to treatment. They classified participants under the "circadian" umbrella if they had at least three of six features: seasonal mood swings, late sleep schedules, social jet lag (a mismatch between sleep routine during workdays and free days), night-owl habits, excessive sleep (hypersomnia), and fatigue upon waking.

A total of 2,604 people fit the proposed subtype. Compared with others in the AGDS cohort, this group was younger and developed depression earlier in life — around 19, compared with about 23 for the rest of the cohort.

The group also skewed female, and individuals reported greater psychological distress, frequent suicidal thoughts and more physical complaints than people who didn't fit the proposed subtype. Some experienced weight gain during depressive episodes and symptoms resembling hypomania, a revved-up state of elevated mood and energy that's milder than full-blown mania.

However, having this constellation of symptoms doesn't mean someone's biological clock is disrupted, said Brant Hasler, a psychologist and sleep researcher at the University of Pittsburgh who was not involved in the study. The researchers relied on the participants' self-reports of their sleep patterns; that data correlates only modestly with direct measures of circadian timing, such as measurements of melatonin in saliva, he said in an email.

"One can identify as an evening-type, and report later sleep timing, and still have physiological circadian timing that is not particularly delayed," he said.

So, in addition to checking symptoms, the team hunted for genetic clues underlying the proposed subtype. They analyzed DNA from participants' saliva samples and calculated "polygenic risk scores," which add up the influence of thousands of different genetic variants to estimate how likely someone is to develop a given condition.

The body's sleep-wake cycle is largely controlled by a hub of cells within the hypothalamus (red). (Image credit: SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY via Getty Images)

"Mental health conditions are shaped by hundreds or thousands of variants that each add a small amount of risk, so everyone carries a unique 'portfolio' of risk," Tonini explained.

People in the circadian group had a higher genetic risk for depression, anxiety, attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder, the analysis suggested. They also had a greater genetic risk of higher body weight, insulin resistance, inflammation, insomnia and late-night sleep habits, compared with the other study participants.

This suggests "circadian depression is more than just 'depression with bad sleep,'" Tonini said. "It involves a mix of metabolic, inflammatory, circadian, and mood-related processes."

Could this change depression treatment?

The researchers looked at the participants' past experiences with antidepressants, finding that the circadian group reported less benefit from common medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). Common examples include the SSRI Lexapro and the SNRI Cymbalta.

The circadian group also experienced more side effects from these treatments, such as drowsiness, nausea, anxiety and weight gain.

"If circadian disruption is a core biological mechanism in these individuals, treatments that fail to address those abnormalities may naturally be less effective," said Dr. Ruth Benca, a psychiatrist and sleep researcher at Wake Forest University School of Medicine who was not involved in the study. However, Benca cautioned that body-clock disruption may not be the only reason standard drugs fall short for these patients.

"People with more pronounced circadian disturbances often have more severe illness and other psychiatric conditions, which can contribute to treatment resistance," Benca told Live Science in an email.

Even so, tracking sleep, measurements of circadian rhythm, and seasonal shifts in mood could help clinicians identify at-risk patients earlier and select more effective treatments sooner in the course of illness, Benca suggested. "Potential approaches include behavioral routines, structured sleep schedules, or chronotherapy," in which the timing of medication or light exposure is strategically coordinated with internal body rhythms, she added.

Clinical trials are still needed to draw firm conclusions about potential treatments, Tonini noted. The findings also must be validated in broader populations, since the study drew on a single Australian cohort and its genetic analysis included only people of European ancestry.

For now, "the study is an important step toward a more personalized treatment approach," she said.

This article is for informational purposes only and is not meant to offer medical advice.

See how much you know about the most complex organ in the human body with our brain quiz!

'> Could 'body clocks' play a role in depression? Study proposes a new 'circadian' subtype
Visits
Online User :
Today Visit :
Week Visit :
Month Visit :
Total Visit :
  • © 2013-2026
  • |
  • Scientific Indexing Services
3505 Brewster Drive, Plano, Texas, 75025, USA